The Role of Transformative Experiences and Brain Network Dynamics in Hedonic Response to Psychedelics: Paving the Way for Broader Utilization

Overview:

This project aims to investigate whether the psychedelic experience is necessary for increased well-being and pleasure and how traits like openness affect this relationship.

Abstract:

Psilocybin, the active psychedelic substance in magic mushrooms thought to induce neuroplasticity, shows promise in treating anhedonia and depression by producing long-lasting mood improvements and transformative experiences. Computational approaches can quantify the underlying brain dynamics, which contribute to the therapeutic effects. However, the intense psychedelic experience poses challenges for widespread use. This project aims to investigate whether the psychedelic experience is necessary for increased well-being and pleasure, whether complex brain dynamics give rise to the experience of pleasure, and how this interaction is influenced by transformative experiences and traits like openness. Psilocybin will be administered with and without a substance to eliminate psychedelic effects, while fMRI will measure brain changes. The study in neurotypical and anhedonic populations seeks to identify crucial factors for effective psychedelic application, inform mechanisms of action, and expedite therapeutic interventions.

Broader Impact:

This project investigates whether the powerful psychedelic experience from psilocybin is necessary for improving mood and pleasure, aiming to make these treatments safer and more accessible to a wider range of people. By understanding how brain activity and personal traits affect the benefits, this research could help develop easier and more effective therapies for those struggling with depression and lack of pleasure in life.